This historic church features twin renaissance towers and murals by famous Vatican artist Johann Schmitt, an early teacher of Frank Duveneck, who was baptised in the parish in 1848. In the spring of 1842, the German congregation purchased a lot at the southwest corner of 6th and Washington streets. On this lot, a new church was constructed. Bishop Flaget of the Diocese of Louisville laid the cornerstone on April 14, 1842. The church was dedicated by the same bishop on October 10, 1842. The new church was brick and measured 100 × 50 feet. Transepts were added to the structure in 1851.