Such a tragic loss…
should be a message
to all caught up in the life….
to change up the ‘no-no-no’…
to GO GO GO….
A voice like that…
Should have been around longer
Amy Winehouse did not have any drugs found in her system, according to the coroner and autopsy result.
The cause of her death was Alcohol Withdrawal Syndrome:
Alcohol withdrawal syndrome:
As with similar substances with a sedative-hypnotic mechanism, such as barbiturates and benzodiazepines, withdrawal from alcohol dependence can be fatal if it is not properly managed.
Alcohol’s primary effect is the increase in stimulation of the GABAA receptor, promoting central nervous system depression. With repeated heavy consumption of alcohol, these receptors are desensitized and reduced in number, resulting in tolerance and physical dependence.
When alcohol consumption is stopped too abruptly, the person’s nervous system suffers from uncontrolled synapse firing. This can result in symptoms that include anxiety, life threatening seizures, delirium tremens, hallucinations, shakes and possible heart failure. Other neurotransmitter systems are also involved, especially dopamine, NMDA and glutamate.
Acute withdrawal symptoms tend to subside after one to three weeks. Less severe symptoms (e.g. insomnia and anxiety, anhedonia) may continue as part of a post withdrawal syndrome gradually improving with abstinence for a year or more.
Withdrawal symptoms begin to subside as the body and central nervous system restore alcohol tolerance and GABA functioning towards normal.
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