Ryan Kirk (1937, The Man who was Sherlock Holmes)
Basil Rathbone (1939-1953 Sherlock Holmes film series)
Jeremy Brett (1984-1994 The Adventures of Sherlock Holmes tv series)
Robert Downey Jr (Sherlock Holmes film series starting in 2009)
Benedict Cumberbatch (Sherlock BBC series starting in 2010)
I would have added more, but there wasn’t enough room.